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HNCIG coordinates major international clinical trials and large-scale collaborative studies that address critical questions in head and neck cancer.

These studies involve multiple cooperative groups and thousands of patients worldwide.

Click here to Propose a Study.
 

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20-003 - Phase III randomised controlled platform trial comparing alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer

Chief Investigator(s): Hisham Mehanna

Contact Email: h.mehanna@bham.ac.uk

Acronym: CompARE

Lead Committee: Scientific Clinical Trials Committee (SCTC)

Study Type: RCT

Population: Advanced

Tumour Type: OPSCC

Status: In progress

21-001 - Prognostic implications of P16 and HPV discordance in oropharyngeal cancer (HNCIG EPIC-OPC): a multicentre, multinational, individual patient data analysis (HNCIG-7)

Chief Investigator(s): Hisham Mehanna, Miren Taberna

Contact Email: h.mehanna@bham.ac.uk

Acronym: EPIC OPC

Lead Committee: Young Investigators Committee (YIC)

Study Type: Real World Data

Population: Curative

Tumour Type: OPSCC

Status: Published

22-003 - Prognostic implications, sensitivity and specificity of extranodal extension detected on radiologic imaging in patients with HPV positive oropharyngeal cancer (HNCIG-ENE): a multinational, multicentre individual patient data analysis (EPIC ENE DATA)

Chief Investigator(s): Hisham Mehanna, Christina Henson, Ahmad K. Abou Foul, Paul Nankivell

Contact Email: Christina-Henson@ouhsc.edu

Acronym: HNCIG iENE RWD

Lead Committee: Young Investigators Committee (YIC)

Study Type: Real World Data

Population: Curative mixed

Tumour Type: HNSSC

Status: Published

18-002 - Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non- inferiority trial

Chief Investigator(s): Maura L Gillison, Andy M Trotti

Contact Email: mgillison@mdanderson.org

Acronym: RTOG 1016

Lead Committee: Scientific Clinical Trials Committee (SCTC)

Study Type: Phase 3 RCT

Population: Curative

Tumour Type: HPV OPC

Status: Published

18-001 - Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer HNCIG (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial

Chief Investigator(s): Hisham Mehanna

Contact Email: h.mehanna@bham.ac.uk

Acronym: De-ESCALaTE

Lead Committee: Scientific Clinical Trials Committee (SCTC)

Study Type: Phase 3 RCT

Population: Curative

Tumour Type: HPV OPC

Status: Published

20-002 - Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus

Chief Investigator(s): Hisham Mehanna, John C. Hardman

Contact Email: h.mehanna@bham.ac.uk

Lead Committee: Guidelines and Protocol Committee (G&PC)

Study Type: Delphi

Population: Curative

Tumour Type: HNSCC

Status: Published