HNCIG-endorsed consensus recommendations for postoperative radiotherapy in HNSCC in the presence of flaps

• Consensus Documents
• Publication

Head and neck reconstructive surgery using a flap is increasingly common. Best practices and outcomes for postoperative radiotherapy (poRT) with flaps have not been specified. We aimed to provide consensus recommendations to assist clinical decision-making highlighting areas of uncertainty in the presence of flaps.

HNCIG Newsletter February 2026

• Newsletter

The HNCIG 2025 Annual Meeting was held on 12–13 November 2025 at the University of Algarve (Penha Campus), Faro, bringing together committee chairs and representatives from across the international HNCIG network. The meeting provided an important...

HNCIG - EPIC HPV OPC Study Video

• Video

HNCIG Newsletter October 2025

• Newsletter

Brief Snapshot of Three Ongoing HNCIG Projects

HNCIG Newsletter April 2025

• Newsletter

Programme now available for HNCIG 2025.

HNCIG consensus recommendations for diagnosing extranodal extension on imaging

• Consensus Documents
• Publication

HNCIG conducted a five-round modified Delphi process with a group of 18 international radiology experts, representing 14 national clinical research groups. We generated consensus recommendations on the terminology and diagnostic criteria for imaging detected extranodal extension to harmonise clinical practice and research. These recommendations have been endorsed by 19 national and international organisations, representing 34 countries.

HNCIG consensus on endpoint definitions in recurrent and metastatic HNSCC trials

• Consensus Documents
• Publication

HNCIG assessed endpoint definitions from phase 3 trials or trials considered practice-changing for patients with recurrent or metastatic mucosal head and neck squamous cell carcinoma, published between 2008 and 2021.

HNCIG consensus guidelines for diagnosing pathologic extranodal extension

• Consensus Documents
• Guidelines
• Publication

HNCIG conducted a three-round modified Delphi process with a group of 19 international pathology experts representing 15 national clinical research groups to generate consensus recommendations for histology detected extranodal extension diagnostic criteria.

HNCIG Consensus on Endpoint Definitions in Curative-intent Trials for HNSCC Published in Lancet Oncology

• Consensus Documents
• Publication

Robust time-to-event endpoint definitions are crucial for the assessment of treatment effect and the clinical value of trial interventions. Here, the Head and Neck Cancer International Group investigated endpoint use in phase 3 trials and trials considered potentially practice-changing published between 2008 and 2021 in the curative-intent setting for patients with mucosal head and neck squamous cell carcinoma. Of the 92 trials reviewed, we show that all core components of endpoint reporting were heterogeneous, including definitions of common terms, such as overall survival and progression-free survival. Our report highlights the urgent need for harmonisation of fundamental components of clinical trial endpoints and the engagement of all stakeholders to ensure the transparent reporting of endpoint details

Essential data variables for a minimum dataset for H&N cancer trails and research

• Consensus Documents
• HNCIG Database
• Publication

HNCIG conducted a five-round modified Delphi process with a group of 18 international radiology experts, representing 14 national clinical research groups. We generated consensus recommendations on the terminology and diagnostic criteria for imaging detected extranodal extension to harmonise clinical practice and research. These recommendations have been endorsed by 19 national and international organisations, representing 34 countries. We propose a new classification system to aid diagnosis, which was supported by most of the participating experts over existing systems, and which will require validation in the future. Additionally, we have created an online educational resource for grading imaging detected extranodal extensions.